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Imatinib-induced bone edema: case report and review of literature

Lucas Vieira dos Santos1, João Paulo Lima, Kathia Cristina Abdalla

  • 1From aHemomed - Instituto de Oncologia e Hematologia & IEP Sao Lucas, Sao Paulo, and the bGastrointestinal Cancer Unit, Medical Oncology Department and cRadiology Department, Hospital de Câncer de Barretos, Barretos, Brazil.

Journal of the National Comprehensive Cancer Network : JNCCN
|October 22, 2013
PubMed

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Cytotoxic edema is a form of cerebral edema characterized by intracellular swelling of neurons, astrocytes, and other glial cells. It develops when the mechanisms responsible for maintaining ionic gradients across the cell membrane become impaired. Under normal physiological conditions, the sodium–potassium ATPase actively transports sodium ions out of the cell and potassium ions into the cell, preserving osmotic balance and enabling electrical signaling. This pump requires a continuous...
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