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Related Concept Videos

Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...
Receptor Downregulation in MVBs01:15

Receptor Downregulation in MVBs

Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that  lead to cell proliferation, migration, and differentiation. Overexpression of EGFR  stimulates cells to proliferate. Excessive  EGFR activation may...
Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...
Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
Complement System01:27

Complement System

The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a membrane...

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Updated: May 12, 2026

CUBIC Protocol Visualizes Protein Expression at Single Cell Resolution in Whole Mount Skin Preparations
08:09

CUBIC Protocol Visualizes Protein Expression at Single Cell Resolution in Whole Mount Skin Preparations

Published on: August 4, 2016

Polymorphism of the complement receptor for C3bi.

G R Russ, A P Haddad, B D Tait

    The Journal of Clinical Investigation
    |November 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    A new mouse antibody, RM2.184, identifies a specific variant of the complement receptor for C3bi on white blood cells. This antigen, found in about 14% of people, is inherited independently of HLA.

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    Last Updated: May 12, 2026

    CUBIC Protocol Visualizes Protein Expression at Single Cell Resolution in Whole Mount Skin Preparations
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    Published on: August 4, 2016

    High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
    07:26

    High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

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    Measuring Erythrocyte Complement Receptor 1 Using Flow Cytometry
    07:20

    Measuring Erythrocyte Complement Receptor 1 Using Flow Cytometry

    Published on: May 19, 2020

    Area of Science:

    • Immunology
    • Cell Biology
    • Genetics

    Background:

    • The complement receptor for C3bi (CR3) is crucial for immune cell function.
    • Monoclonal antibodies are key tools for characterizing cell surface antigens.
    • Understanding CR3 polymorphism aids in studying immune responses and genetic variations.

    Purpose of the Study:

    • To characterize a novel polymorphic determinant on the complement receptor for C3bi.
    • To define the epitope recognized by the mouse monoclonal antibody RM2.184.
    • To investigate the inheritance pattern of the RM2.184 antigen.

    Main Methods:

    • Hybridoma technology for monoclonal antibody production (RM2.184).
    • Immunological assays to determine epitope specificity and cellular expression (granulocytes, monocytes).
    • Family studies to analyze antigen segregation and inheritance patterns.

    Main Results:

    • RM2.184 recognizes a polymorphic epitope on the CR3 receptor, distinct from the OKM1 epitope.
    • The epitope is likely located on the alpha subunit and requires subunit association for integrity.
    • The RM2.184 antigen has a phenotypic frequency of approximately 14%.
    • Segregation analysis indicates an autosomal co-dominant inheritance, independent of HLA.

    Conclusions:

    • RM2.184 provides a valuable tool for studying CR3 polymorphism.
    • The identified antigen variant has implications for understanding immune cell heterogeneity.
    • The genetic basis of this CR3 polymorphism follows an autosomal co-dominant inheritance pattern.