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Related Concept Videos

Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

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Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
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Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Peripheral Artery Disease IV: Nursing Management01:26

Peripheral Artery Disease IV: Nursing Management

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 The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...
714
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

663
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
663
Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists01:23

Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists

618
Prostacyclin receptor agonists are a class of therapeutic agents integral to managing pulmonary arterial hypertension (PAH). These drugs operate by mimicking the action of prostaglandin I2, or PGI2, a naturally occurring compound in the body.
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
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Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

637
During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
637

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Computerized Dynamic Posturography for Postural Control Assessment in Patients with Intermittent Claudication
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PURLs: ramipril for claudication?

Luke A Stephens1, Nina Rogers, James J Stevermer

  • 1Department of Family and Community Medicine, University of Missouri, Columbia, MO, USA.

The Journal of Family Practice
|October 22, 2013
PubMed
Summary
This summary is machine-generated.

Angiotensin-converting enzyme (ACE) inhibitors can improve walking distance and reduce pain for individuals with peripheral artery disease. This medication offers a new treatment option for enhanced mobility in patients with this condition.

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Area of Science:

  • Cardiovascular Medicine
  • Pharmacology

Background:

  • Peripheral artery disease (PAD) significantly impairs quality of life due to leg pain during ambulation.
  • Limited effective pharmacological treatments exist to improve walking capacity in PAD patients.

Purpose of the Study:

  • To evaluate the efficacy of a specific ACE inhibitor in improving pain-free walking distance in patients with peripheral artery disease.

Main Methods:

  • A randomized controlled trial was conducted involving patients diagnosed with peripheral artery disease.
  • Participants received either the ACE inhibitor or a placebo.
  • Pain-free walking distance was assessed using a standardized treadmill test.

Main Results:

  • Patients treated with the ACE inhibitor demonstrated a statistically significant increase in pain-free walking distance compared to the placebo group.
  • No major adverse events were reported in the ACE inhibitor group.

Conclusions:

  • The studied ACE inhibitor is an effective therapeutic option for improving walking performance and alleviating pain in patients with peripheral artery disease.
  • This finding suggests a potential new pharmacological strategy to manage PAD symptoms and enhance patient mobility.