[Moebius syndrome. Clinical case report]

Area of Science:

• Neurology
• Genetics
• Teratology

Background:

• Moebius syndrome (MBS) is a rare congenital disorder affecting cranial nerves, with an incidence of 1 in 10,000 births.
• Characterized by congenital bilateral facial paralysis due to agenesis of the sixth and seventh cranial nerves.
• Frequently associated with orofacial and limb anomalies, diagnosis relies on clinical manifestations.

Observation:

• A case of a female newborn presenting with Moebius syndrome is detailed.
• The discussion includes potential genetic or environmental factors contributing to MBS.
• An observed increase in MBS cases linked to misoprostol use, often with NSAIDs, for abortion or labor induction.

Findings:

• The clinical presentation of Moebius syndrome in the newborn.
• Exploration of the association between maternal drug use (misoprostol, NSAIDs) and MBS development.
• Highlights the potential teratogenic effects of misoprostol.

Implications:

• Emphasizes the need for medical and public awareness regarding misoprostol's teratogenic risks.
• Underscores the importance of genetic counseling for newborns diagnosed with Moebius syndrome.
• Suggests further research into the environmental and genetic etiologies of Moebius syndrome.