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Updated: May 6, 2026

Protocol to Create Chronic Wounds in Diabetic Mice
Published on: September 25, 2019
Background:
This article summarizes information presented at the Wound Healing Subspecialty Symposium of the Annual Conference of the Canadian Dermatology Association held in Ottawa in June 2012.
Objective:
To provide continuing medical education on wound healing for dermatologists.
Methods:
A review of the pertinent literature was performed by the author in order to prepare the lecture and subsequent article.
Results:
The review found that necrotizing faciitis, hypertensive ulceration, antiphospholipid syndrome and α1-antitrypsin syndrome are entities that contribute to catastrophic wounds seen in wound healing clinics and in private offices.
Conclusion:
It is most important to have a high index of suspicion for these four conditions because early diagnosis can be life-saving with necrotizing faciitis, pain-relieving in ulcers caused by hypertension, and antiphospholipid syndrome, and can result in early treatment in α1-antitrypsin deficiency.
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