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Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
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Related Experiment Video

Updated: May 6, 2026

Myocardial Infarction in Neonatal Mice, A Model of Cardiac Regeneration
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Myocardial dysfunction in pediatric septic shock.

Shashi Raj1, James S Killinger1, Jennifer A Gonzalez2

  • 1Division of Pediatric Critical Care Medicine, Department of Pediatrics, The Children's Hospital at Montefiore, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY.

The Journal of Pediatrics
|October 23, 2013
PubMed
Summary
This summary is machine-generated.

Myocardial dysfunction is common in children with septic shock, affecting over half of patients. This cardiac issue was linked to higher troponin levels and acute kidney injury but did not impact hospital stay duration.

Keywords:
AEEFEjection fractionIVALVLeft ventricularMPIMitral valve annular acceleration during isovolumic contractionMitral valve annular velocity during systoleMitral valve annular velocity in early diastoleMitral valve annular velocity in late diastoleMitral valve inflow velocity in early diastoleMitral valve inflow velocity in late diastoleMyocardial performance indexPCCUPELODPediatric Logistic Organ DysfunctionPediatric Risk, Injury, Failure, Loss, and End-Stage Kidney DiseasePediatric critical care unitRVRight ventricularTTETransthoracic echocardiographypRIFLEáéś

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Real-time Pressure-volume Analysis of Acute Myocardial Infarction in Mice
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Area of Science:

  • Pediatric Critical Care Medicine
  • Cardiology
  • Septic Shock Research

Background:

  • Septic shock in children can lead to multi-organ dysfunction.
  • The impact of myocardial dysfunction in pediatric septic shock requires further investigation.

Purpose of the Study:

  • To determine the prevalence of myocardial dysfunction in pediatric septic shock.
  • To assess the association between myocardial dysfunction and clinical outcomes in these patients.

Main Methods:

  • Transthoracic echocardiography was used to evaluate left ventricular (LV) systolic and diastolic function in 30 children with septic shock.
  • Dysfunction was defined using z-scores for ejection fraction, shortening fraction, and diastolic inflow/annular velocities.
  • Secondary outcomes included troponin I levels, acute kidney injury, and mechanical ventilation duration.

Main Results:

  • The prevalence of left ventricular systolic and/or diastolic dysfunction was 53% in children with septic shock.
  • Myocardial dysfunction was significantly associated with elevated troponin I levels (P = .007) and acute kidney injury (P = .02).
  • No significant difference was observed in pediatric critical care unit or hospital length of stay between patients with and without myocardial dysfunction.

Conclusions:

  • Myocardial dysfunction is a frequent complication in pediatric septic shock.
  • While associated with certain biomarkers and complications, myocardial dysfunction may not significantly influence hospital length of stay in this population.