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Published on: October 26, 2017
[Detection of plasma cofilin protein for diagnosis of lung cancer]
Yuju Zheng1, Ye Fang, Shaojin Li
1Department of Cardiothoracic Surgery, Shantou Chaonan Mingsheng Hospital; First Affiliated Hospital of Shantou University Medical College, Shantou 515041, China.
Objective:
To detect serum content of cofilin protein in patients with lung cancer and investigate its clinical value.
Methods:
The serum content of cofilin protein was detected in 30 cases of lung cancer and 30 healthy control subjects using enzyme-linked immunosorbent assay.
Results:
The mean serum content of cofilin protein was 0.485∓0.465 ng/ml in patients with lung cancer and 0.203∓0.102 ng/ml in the control subjects, showing a significant difference between them (P<0.05). The content of cofilin protein in patients with stage III and IV lung cancer 0.744∓0.584 ng/ml, significantly higher than that in stage II patients (0.257∓0.126 ng/ml).
Conclusion:
Serum cofilin protein is elevated in patients with lung cancer, especially in cases in advanced stages, suggesting its relation with lung cancer staging.
