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Brain Imaging

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...

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Developing epigenetic diagnostics and therapeutics for brain disorders.

Irfan A Qureshi¹, Mark F Mehler

¹Roslyn and Leslie Goldstein Laboratory for Stem Cell Biology and Regenerative Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Institute for Brain Disorders and Neural Regeneration, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Rose F. Kennedy Center for Research on Intellectual and Developmental Disabilities, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Trends in Molecular Medicine

|October 23, 2013

Summary

This summary is machine-generated.

Epigenetic signatures in brain disorders offer valuable biomarkers for early diagnosis and targeted treatments. These molecular markers can track disease progression and treatment effectiveness, paving the way for new therapies.

Keywords:

bromodomain epigenomic exosome glioma histone deacetylase long non-coding RNA microRNA

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Area of Science:

Neuroscience
Molecular Pathology
Epigenetics

Background:

Epigenetic mechanisms are fundamentally altered in major brain disorders.
These alterations play a key role in the molecular pathology of neurological and psychiatric conditions.

Purpose of the Study:

To review the evidence for epigenetic signatures as translatable biomarkers in brain disorders.
To discuss the therapeutic potential of targeting epigenetic factors and mechanisms.

Main Methods:

Literature review focusing on epigenetic alterations in brain disorders.
Analysis of studies investigating epigenetic biomarkers in central and peripheral tissues.
Examination of current and emerging epigenetic therapeutic strategies.

Main Results:

Specific epigenetic signatures are measurable and hold significant value as biomarkers.
These biomarkers are useful for screening, diagnosis, prognostication, and monitoring disease/treatment response.
Therapeutic approaches targeting DNA methylation, histone modifications, and non-coding RNAs are advancing.

Conclusions:

Epigenetic biomarkers have substantial potential for clinical application in brain disorder management.
Targeting epigenetic mechanisms offers promising avenues for novel therapeutic interventions.
Further research into epigenetic signatures can revolutionize the diagnosis and treatment of brain disorders.