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Updated: May 6, 2026
FISH for Pre-implantation Genetic Diagnosis
Published on: February 23, 2011
Indications for invasive prenatal diagnostic procedures at a dedicated fetal medicine centre: an 8 year audit
Vijayan Valayatham1, Raman Subramaniam, Yap Moy Juan
1Sabah Women & Children Hospital (Likas), PO Box 187, 88996, Kota Kinabalu, Sabah, Malaysia. vj1vela@gmail.com.
Objective:
Analyze indications and type of prenatal diagnostic procedures performed.
Method:
This retrospective audit was conducted at a dedicated fetal medicine center in Petaling Jaya. All invasive prenatal diagnosis procedures performed from 2003 up until 2010 (amniocentesis, chorionic villous sampling and fetal blood sampling) were analyzed.
Result:
A total of 1560 invasive prenatal diagnostic procedures were performed during the 8 year period. Advanced maternal age is the leading indication for invasive prenatal diagnostic procedures followed by fetal abnormalities. The fetal loss rate was 0.2% for amniocentesis and 1.2% for CVS.
Conclusion:
Advanced maternal age is the leading indication for invasive prenatal diagnostic procedures at this centre but is on a declining trend. The fetal loss rates are comparable to auditable standards set by professional bodies, in this case, the Royal College of Obstetricians & Gynecologists of London.
