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Modeling Chemotherapy Resistant Leukemia In Vitro
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Paraneoplastic leukemoid reaction in solid tumors.

Subhankar Chakraborty1, Brent Keenportz, Suzette Woodward

  • 1*Department of Internal Medicine, University of Nebraska Medical Center, Omaha †Department of Pathology, Saint Francis Medical Center ‡Internal Medical Associates of Grand Island, Grand Island, NE.

American Journal of Clinical Oncology
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Summary
This summary is machine-generated.

Paraneoplastic leukemoid reaction, a severe leukocytosis (>50,000/μL) linked to cancer, was observed in a patient with metastatic carcinoma. This case highlights the importance of ruling out malignancy in such cases.

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Area of Science:

  • Oncology
  • Hematology

Background:

  • Leukemoid reaction is defined as a white blood cell count exceeding 50,000/μL.
  • Paraneoplastic leukemoid reaction is diagnosed when leukemoid reaction is associated with malignancy, excluding infection or leukemia.

Observation:

  • A patient presented with fatigue, weakness, and abdominal distension.
  • Incidental finding of a white blood cell count of 139,000/μL.
  • Leukemia was excluded via peripheral smear and flow cytometry.

Findings:

  • Computed tomography-guided omental biopsy revealed poorly differentiated metastatic carcinoma.
  • The patient experienced a rapid decline, with a peak white blood cell count of 180,000/μL.
  • Death occurred 3 days post-admission.

Implications:

  • This case underscores the significance of considering paraneoplastic leukemoid reaction in the differential diagnosis of severe leukocytosis.
  • Further review of existing literature and pathophysiology is warranted.
  • Early recognition and management of underlying malignancy are crucial for patient outcomes.