Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Investigation of Disease Outbreaks

Investigation of Disease Outbreaks

Multistate foodborne outbreaks pose significant public health risks and require meticulous investigation to identify sources and implement control measures. The Centers for Disease Control and Prevention (CDC) utilizes a dynamic seven-step process for these investigations, integrating data from laboratories, interviews, and environmental assessments to protect public health.Outbreak Detection: The detection of multistate outbreaks typically begins with PulseNet, the CDC's national laboratory...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Conflict wounds and antimicrobial resistance: a systematic review on local antimicrobials to prevent infection after extremity open fracture.

BMJ military health·2026

Same author

Comment on: Resistance profiles of carbapenemase-producing Enterobacterales in a large centre in England: are we already losing cefiderocol?

The Journal of antimicrobial chemotherapy·2025

Same author

Addressing the challenge of antimicrobial resistance.

Communications medicine·2025

Same author

Integrated Analysis of Patient Networks and Plasmid Genomes to Investigate a Regional, Multispecies Outbreak of Carbapenemase-Producing Enterobacterales Carrying Both blaIMP and mcr-9 Genes.

The Journal of infectious diseases·2024

Same author

Conflict and catastrophe-related severe burn injuries: A challenging setting for antimicrobial decision-making.

The Journal of infection·2024

Same author

The Management of Patients at High Risk of Serious COVID-19 Disease: Optimising the Patient Pathway in the Middle East, Africa, and Eastern Europe.

Cureus·2024

Same journal

Beyond the High: A Narrative Review of the Chronic Complications of Recreational Ketamine Use.

British journal of hospital medicine (London, England : 2005)·2026

Same journal

Prolonged Undiagnosed Prodromal Symptoms.

British journal of hospital medicine (London, England : 2005)·2026

Same journal

Human Factors and Deterioration: What Success Factors Facilitate Escalation of Care and How Can These Be Applied More Reliably?

British journal of hospital medicine (London, England : 2005)·2026

Same journal

Comparative Evaluation of Functional Outcomes and Postoperative Complications After Minimally Invasive Fixation for Acromioclavicular Joint Injuries.

British journal of hospital medicine (London, England : 2005)·2026

Same journal

A Systematic Review of Functional MRI Studies on Seasonal Modulation of Brain Functional Connectivity.

British journal of hospital medicine (London, England : 2005)·2026

Same journal

More Than Myocarditis? Cardiac Involvement in Phaeochromocytoma-A Case Report.

British journal of hospital medicine (London, England : 2005)·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 6, 2026

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment

Published on: May 25, 2017

Investigating Clostridium difficile.

Luke Sp Moore¹, Hugo Donaldson

¹NIHR Imperial BRC Clinical Research Fellow in the National Centre for Infection Prevention and Management, Imperial College London, London.

British Journal of Hospital Medicine (London, England : 2005)

|October 23, 2013

Summary

This summary is machine-generated.

Clostridium difficile infection (CDI) is a major healthcare concern. This review clarifies diagnostic approaches for CDI to improve patient care and reduce confusion.

More Related Videos

Culturing and Maintaining Clostridium difficile in an Anaerobic Environment

Culturing and Maintaining Clostridium difficile in an Anaerobic Environment

Published on: September 14, 2013

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

Published on: December 10, 2016

Related Experiment Videos

Last Updated: May 6, 2026

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment

Published on: May 25, 2017

Culturing and Maintaining Clostridium difficile in an Anaerobic Environment

Culturing and Maintaining Clostridium difficile in an Anaerobic Environment

Published on: September 14, 2013

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

Published on: December 10, 2016

Area of Science:

Medical Microbiology
Infectious Diseases
Clinical Diagnostics

Background:

Clostridium difficile is a leading cause of healthcare-associated infections (HAIs) in the UK.
CDI presents significant clinical and economic burdens.
Current laboratory testing strategies for CDI are debated, leading to diagnostic challenges.

Purpose of the Study:

To review the clinical presentation of Clostridium difficile infection.
To evaluate available diagnostic tests for CDI.
To provide guidance on interpreting test results for bedside clinical management.

Main Methods:

Literature review of disease presentation and diagnostic modalities for CDI.
Analysis of current controversies in laboratory testing for Clostridium difficile.
Synthesis of information to aid clinical decision-making.

Main Results:

Clostridium difficile infection (CDI) presents with varied clinical symptoms.
Multiple diagnostic tests exist, each with advantages and limitations.
Interpretation of diagnostic results requires careful consideration of the clinical context.

Conclusions:

Optimal diagnostic strategies for CDI are crucial for effective patient management.
Understanding disease presentation and test performance aids in reducing diagnostic uncertainty.
Evidence-based interpretation of CDI tests can improve clinical outcomes.