Early-life factors associated with pediatric functional constipation

Area of Science:

• Pediatrics
• Gastroenterology
• Infant Health

Background:

• Functional constipation (FC) is a common pediatric concern.
• Identifying risk factors for FC in infants is crucial for early intervention.

Purpose of the Study:

• To determine risk factors associated with functional constipation (FC) during an infant's first year of life.

Main Methods:

• A multicenter prospective study involving 465 infants at 3 and 6 months, and 402 at 12 months.
• Parents completed questionnaires on FC presence and potential risk factors.
• Rome III criteria were used to diagnose FC.

Main Results:

• FC prevalence was 10.7-13.7% throughout the first year.
• Family history of atopy showed association at 3 and 6 months.
• Acetaminophen use and female sex were identified as risk factors for FC at 12 months, with acetaminophen use significantly associated (OR 6.98).

Conclusions:

• Breast-feeding acts as a protective factor against FC in the initial three months of life.
• Female infants are at a higher risk for developing FC.
• Acetaminophen use is linked to an increased incidence of FC in infants.