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Platelets and hypertension.

P Erne, T J Resink, E Bürgisser

    Journal of Cardiovascular Pharmacology
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Platelets from individuals with hypertension show abnormal calcium-dependent functions, including altered responses to hormones like epinephrine and serotonin. These platelet anomalies are linked to higher intracellular calcium levels in hypertension.

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    Area of Science:

    • Cardiovascular Physiology
    • Cellular Biology
    • Biochemistry

    Background:

    • Platelets and vascular smooth muscle cells share physiological characteristics.
    • Essential hypertension is associated with an increased risk of thromboembolic complications.
    • Platelets serve as a valuable experimental model for studying hypertension-related anomalies.

    Purpose of the Study:

    • To investigate calcium-dependent functional anomalies in platelets from hypertensive subjects.
    • To analyze receptor and postreceptor events in platelet function during hypertension.
    • To understand the role of calcium in platelet dysfunction in hypertension.

    Main Methods:

    • Sequential analysis of receptor and postreceptor signaling pathways in platelets.
    • Assessment of adenylate cyclase activation and cyclic AMP accumulation in response to PGE1.

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  • Evaluation of epinephrine-induced phosphorylation and shape change sensitivity to serotonin and epinephrine.

    • Main Results:

    • Platelets from hypertensive subjects exhibited a greater adenylate cyclase-activation and cyclic AMP accumulation response to PGE1.
    • Enhanced epinephrine-induced phosphorylation was observed in platelets from hypertensive individuals.
    • Increased shape change sensitivity to serotonin and epinephrine was noted in hypertensive platelets.
    • These calcium-dependent anomalies correlate with elevated free intracellular calcium concentrations.

    Conclusions:

    • Hypertension is associated with specific calcium-dependent functional anomalies in platelets.
    • Elevated intracellular calcium levels in platelets contribute to observed functional abnormalities in hypertension.
    • Platelet dysfunction may play a role in the thromboembolic complications associated with hypertension.