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Metabolomics in drug discovery and development
1Applied and Investigative Metabolomics, Bristol-Myers Squibb, Princeton, New Jersey, USA.
Clinical Pharmacology and Therapeutics
|October 23, 2013
Summary
Metabolomics is revolutionizing drug discovery and development by assessing biochemical effects and improving biologic manufacturing. Further technological innovation and acceptance are key to fully leveraging this powerful tool for pharmaceutical applications.
Area of Science:
- Biochemistry
- Pharmacology
- Biotechnology
Background:
- Metabolomics is increasingly integral to pharmaceutical research and development.
- Its applications span from early-stage target validation to late-stage biomanufacturing.
- The scope of metabolomics in drug discovery is rapidly expanding.
Purpose of the Study:
- To highlight the expanding role of metabolomics in drug discovery and development.
- To outline critical pharmaceutical applications of metabolomics.
- To emphasize the need for technological advancement and adoption.
Main Methods:
- Utilizing metabolomics for assessing biochemical sequelae in transgenic models.
- Employing metabolomics for monitoring media content in biologic manufacturing.
- Applying metabolomics in translational medicine and biomarker discovery.
Main Results:
- Metabolomics enables the assessment of unexpected biochemical outcomes during drug target engagement.
- It enhances the efficiency of biologic manufacturing through media content monitoring.
- Key pharmaceutical applications include translational medicine, biomarker discovery, and patient stratification.
Conclusions:
- Metabolomics technology offers significant value across the drug discovery and development pipeline.
- Its successful implementation requires ongoing technological innovation.
- Cultural acceptance and integration are crucial for maximizing the impact of metabolomics.
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