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[Acute and chronic heart failure in light of the new ESC guidelines]

J Pöss1, A Link, M Böhm

  • 1Klinik für Innere Medizin III, Kardiologie, Angiologie und internistische Intensivmedizin, Universitätsklinikum des Saarlandes, Kirrbergerstr., 66421, Homburg/Saar, Deutschland, janine.poess@uks.eu.

Herz
|October 23, 2013
PubMed

Insights

New European heart failure guidelines recommend mineralocorticoid receptor antagonists for chronic heart failure and ivabradine for specific patient groups. The RELAX-AHF trial shows promise for serelaxin in acute heart failure treatment.

Area of Science:

  • Cardiology
  • Clinical Trials
  • Pharmacology

Context:

  • The European Society of Cardiology updated its heart failure treatment guidelines in June 2012.
  • Existing treatments for chronic and acute heart failure are being re-evaluated based on recent clinical trial data.

Purpose:

  • To summarize key innovations in the 2012 European Society of Cardiology guidelines for heart failure.
  • To review the pivotal clinical trials informing these new treatment recommendations.

Summary:

  • Mineralocorticoid receptor antagonists are now indicated for all stages of symptomatic chronic heart failure (EMPHASIS-HF trial).
  • Ivabradine is recommended for heart failure patients (NYHA II-IV, ejection fraction <35%, heart rate >70/min) on beta-blockers (SHIFT trial).
  • Cardiac resynchronization therapy (CRT) indications are expanded (RAFT trial), and serelaxin shows promise for acute heart failure (RELAX-AHF trial).

Impact:

  • These guideline updates provide clinicians with evidence-based strategies for optimizing heart failure management.
  • The integration of new trial data aims to improve patient outcomes in both chronic and acute heart failure settings.

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