Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cardiopulmonary Resuscitation III: AED Use01:23

Cardiopulmonary Resuscitation III: AED Use

1.7K
Introduction to AEDAn Automated External Defibrillator (AED) is a portable medical device that analyzes the heart's rhythm and, if necessary, delivers an electrical shock to help the heart re-establish an effective rhythm during sudden cardiac arrest (SCA). SCA occurs when the heart suddenly and unexpectedly stops beating, leading to a loss of blood flow to the brain and other vital organs. In such emergencies, time is of the essence, and using an AED, combined with Cardiopulmonary...
1.7K
Cardiopulmonary Resuscitation IV: Pharmacological Management01:25

Cardiopulmonary Resuscitation IV: Pharmacological Management

1.7K
Pharmacologic intervention is crucial in treating cardiac arrest patients during ACLS or Advanced Cardiovascular Life Support. The ACLS algorithms guide the administration of specific drugs based on the patient's cardiac arrest rhythm, which includes pulseless ventricular tachycardia (VT), ventricular fibrillation (VF), asystole, and pulseless electrical activity (PEA).EpinephrineIndication: Epinephrine is the first-line drug for all cardiac arrest rhythms.Mechanism of Action: Epinephrine...
1.7K
Dysrhythmias VI: Management of Dysrhythmias01:25

Dysrhythmias VI: Management of Dysrhythmias

599
Dysrhythmia management involves a multifaceted approach, incorporating pharmacological treatments, medical procedures, surgical interventions, lifestyle modifications, and patient education.Pharmacological ManagementAntiarrhythmic Drugs:Class I (Sodium Channel Blockers): This class includes quinidine and procainamide, which reduce the speed of impulse conduction in the heart, stabilize the cardiac membrane, and control arrhythmias. Quinidine and procainamide are Class IA agents that prolong the...
599

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Catheter ablation of epicardial premature ventricular complexes in patients with and without cardiac scar.

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing·2026
Same author

Focal pulsed field ablation for atrial tachycardia near the phrenic nerve: a two-case experience.

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing·2026
Same author

Regional and racial outcomes in mortality after atrial fibrillation ablation in medicare Fee for service patients.

Frontiers in cardiovascular medicine·2026
Same author

Multimodality Image Integration of FDG-PET and CMR Into Electroanatomic Mapping Identifies Electrophysiologic Signatures of Myocardial Inflammation in Cardiac Sarcoidosis.

JACC. Cardiovascular imaging·2026
Same author

T-Sign: A Novel CMR Scar Pattern With Favorable Outcomes During Ventricular Tachycardia Ablation in Cardiac Sarcoidosis.

JACC. Clinical electrophysiology·2026
Same author

Bachmann's Bundle-Related Atrial Tachycardias Following Catheter Ablation of Persistent Atrial Fibrillation.

Journal of cardiovascular electrophysiology·2026
Same journal

Outcomes of conduction system and right ventricular pacing in bradyarrhythmia indications: A systematic review and meta-analysis of propensity-score matched and randomized studies.

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing·2026
Same journal

Single-shot ablation for AF: Real-world procedural and one-year outcomes with the newly adopted PulseSelect PFA compared with cryoballoon from the 1STOP project.

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing·2026
Same journal

Sex differences in escalation to atrioventricular node ablation following catheter ablation for atrial fibrillation.

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing·2026
Same journal

Focal pulsed field ablation for complex ventricular arrhythmias after prior failed or intraprocedurally ineffective radiofrequency ablation.

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing·2026
Same journal

Machine learning prediction of mechanical dilatation in transvenous lead extraction for cardiac device-related infections: insights from a high-volume centre.

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing·2026
Same journal

Heterogeneity in endpoints, monitoring methods and blanking periods in clinical trials of atrial fibrillation ablation: a systematic review and meta-analysis.

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing·2026
See all related articles

Related Experiment Video

Updated: May 6, 2026

A Model of Long-Term Ventricular Fibrillation in Isolated Rat Hearts
07:56

A Model of Long-Term Ventricular Fibrillation in Isolated Rat Hearts

Published on: February 17, 2023

1.4K

The relationship between defibrillation threshold and total mortality.

Jason C Rubenstein1, Michael H Kim, Fred Morady

  • 1Medical College of Wisconsin, Milwaukee, WI, USA, jrubenstein@mcw.edu.

Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing
|October 23, 2013
PubMed
Summary
This summary is machine-generated.

High implant defibrillation threshold (DFT) in patients with implantable cardioverter-defibrillators (ICDs) is linked to increased mortality. This finding holds true even when a sufficient safety margin for the ICD is achieved.

More Related Videos

A Rat Model of Ventricular Fibrillation and Resuscitation by Conventional Closed-chest Technique
09:47

A Rat Model of Ventricular Fibrillation and Resuscitation by Conventional Closed-chest Technique

Published on: April 26, 2015

15.2K
A New Single Chamber Implantable Defibrillator with Atrial Sensing: A Practical Demonstration of Sensing and Ease of Implantation
16:40

A New Single Chamber Implantable Defibrillator with Atrial Sensing: A Practical Demonstration of Sensing and Ease of Implantation

Published on: February 28, 2012

27.5K

Related Experiment Videos

Last Updated: May 6, 2026

A Model of Long-Term Ventricular Fibrillation in Isolated Rat Hearts
07:56

A Model of Long-Term Ventricular Fibrillation in Isolated Rat Hearts

Published on: February 17, 2023

1.4K
A Rat Model of Ventricular Fibrillation and Resuscitation by Conventional Closed-chest Technique
09:47

A Rat Model of Ventricular Fibrillation and Resuscitation by Conventional Closed-chest Technique

Published on: April 26, 2015

15.2K
A New Single Chamber Implantable Defibrillator with Atrial Sensing: A Practical Demonstration of Sensing and Ease of Implantation
16:40

A New Single Chamber Implantable Defibrillator with Atrial Sensing: A Practical Demonstration of Sensing and Ease of Implantation

Published on: February 28, 2012

27.5K

Area of Science:

  • Cardiology
  • Medical Devices
  • Electrophysiology

Background:

  • The prognostic significance of defibrillation threshold (DFT) in patients with implantable cardioverter-defibrillators (ICDs) remains incompletely understood.
  • Investigating the correlation between DFT and overall mortality is crucial for patient management.

Purpose of the Study:

  • To determine if implant DFT is an independent predictor of mortality in patients receiving ICDs.
  • To explore the relationship between varying levels of implant DFT and patient survival outcomes.

Main Methods:

  • A prospective analysis of 508 patients undergoing ICD implantation with recorded DFT.
  • Patients were stratified into three groups based on implant DFT: high (≥20 J), moderate (19-11 J), and low (≤10 J).
  • Survival data and potential confounding factors were collected and analyzed over a mean follow-up of 3.2 years.

Main Results:

  • A total of 140 deaths occurred during the follow-up period.
  • The high DFT group exhibited a significantly higher mortality rate (35.8%) compared to the moderate (28.7%) and low (24.0%) DFT groups (p=0.05).
  • Implant DFT emerged as a significant independent predictor of mortality (p=0.004), alongside age, LVEF, CAD, amiodarone use, and hematoma at implant.

Conclusions:

  • Elevated implant DFT is associated with an adverse prognosis and predicts increased mortality risk.
  • This association persists even when an adequate safety margin for ICD function is confirmed.
  • The findings underscore the importance of considering implant DFT as a prognostic marker in ICD patients.