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Related Concept Videos

Ophthalmic Drug Delivery Systems01:23

Ophthalmic Drug Delivery Systems

285
Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...
285

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Related Experiment Video

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Ultrasound Cyclo Plasty in Eyes with Glaucoma
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[Cycloplegia using a conjunctival insert - comparison to standard procedures].

J Leu1, J Schaal

  • 1Orthoptik, Augenarztpraxis Dr. Leu, Beelitz.

Klinische Monatsblatter Fur Augenheilkunde
|October 23, 2013
PubMed
Summary

A new conjunctival insert for mydriasis and cycloplegia was tested. While less effective and slower than eye drops, it offers an alternative for patients with instillation difficulties.

Area of Science:

  • Ophthalmology
  • Pharmacology
  • Drug Delivery Systems

Background:

  • Tropicamide and phenylephrine eye drops are standard for preoperative mydriasis and cycloplegia.
  • A novel conjunctival insert, Mydriasert, offers a new drug delivery form for inducing cycloplegia.

Purpose of the Study:

  • To evaluate the efficacy and onset of cycloplegia induced by the Mydriasert conjunctival insert compared to standard eye drops.
  • To assess patient comfort with the new conjunctival insert application form.

Main Methods:

  • Prospective study involving 10 patients (aged 5-41) with residual accommodation.
  • One eye received the conjunctival insert, the other received tropicamide/phenylephrine eye drops.
  • Pupil width and accommodation were measured every 15 minutes; refraction assessed at minimal accommodation.

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Main Results:

  • The conjunctival insert showed less cycloplegic power (accommodation lag 3.16 D) compared to eye drops (2.61 D) and atropine (1.5 D).
  • Maximal cycloplegia was delayed with the insert (60 min) versus eye drops (45 min).
  • Patient comfort was reported as similar for both application methods.

Conclusions:

  • The conjunctival medicament insert provides a novel method for inducing cycloplegia.
  • Its effect is less potent and slower than standard eye drops.
  • Consideration for specific patients, particularly those for whom eye drop instillation is challenging, is warranted.