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Study on in-vivo anti-tumor activity of Verbena officinalis extract
Wei-Zheng Kou1, Jun Yang, Qing-Hui Yang
1Department of Oncology, First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, Henan, China.
Abstract:
We investigated the anti-tumor effects of Verbena officinalis extract on H22 tumor-bearing mice and its effect on immune function. Mice model of H22 solid tumor was established, the mice were divided into five groups and administered the extract, later, tumors were removed and inhibition rates were calculated; spleens were removed and spleen indices were calculated, and the sheep red blood cell-delayed-type hypersensitivity (SRBC-DTH) and the serum hemolysin level were determined. The Verbena officinalis extract had anti-tumor effect, with the inhibition rate reaching 38.78%, it also increased the spleen index to a certain extent, in addition, the changes in DTA and HA were not obvious compared with the model group. The Verbena officinalis extract had in vivo anti-tumor effect, while causing no damage on the immune function.
Insights
Verbena officinalis extract demonstrated anti-tumor effects in mice, inhibiting tumor growth by 38.78%. Importantly, this natural compound enhanced spleen index without compromising overall immune function.
Area of Science:
- Pharmacology
- Immunology
- Natural Product Research
Background:
- The H22 solid tumor mouse model is frequently used to evaluate anti-cancer agents.
- Investigating natural compounds for therapeutic potential is a growing area in cancer research.
Purpose of the Study:
- To assess the anti-tumor efficacy of Verbena officinalis extract in a murine cancer model.
- To determine the impact of Verbena officinalis extract on key immune function indicators.
Main Methods:
- Establishment of an H22 solid tumor mouse model.
- Administration of Verbena officinalis extract to different treatment groups.
- Measurement of tumor inhibition rate, spleen index, sheep red blood cell-delayed-type hypersensitivity (SRBC-DTH), and serum hemolysin levels.
Main Results:
- Verbena officinalis extract exhibited a significant anti-tumor effect, achieving a 38.78% inhibition rate.
- The extract moderately increased the spleen index in tumor-bearing mice.
- No significant adverse effects on SRBC-DTH and serum hemolysin levels were observed compared to the control group.
Conclusions:
- Verbena officinalis extract possesses in vivo anti-tumor properties.
- The extract demonstrates potential as an anti-cancer agent without negatively impacting immune function.
