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Bone mineral density and coronary atherosclerosis
Shokoofeh Hajsadeghi1, Mohamad-Ebrahim Khamseh, Bagher Larijani
1Department of Cardiology, Tehran University of Medical Sciences, Tehran, Iran.
Insights
Low bone mineral density (BMD) was not significantly associated with coronary artery disease (CAD) in patients undergoing angiography. The prevalence of low BMD did not differ between those with and without obstructive CAD.
Area of Science:
- Cardiovascular Medicine
- Endocrinology
- Radiology
Background:
- The relationship between low bone mineral density (BMD) and atherosclerosis remains unclear.
- This study investigates BMD in patients with and without coronary artery atherosclerosis.
Purpose of the Study:
- To determine if low bone mineral density is associated with coronary artery atherosclerosis.
- To compare BMD in patients with and without obstructive coronary artery disease (CAD).
Main Methods:
- 123 patients undergoing coronary angiography were assessed using dual X-ray absorptiometry (DXA).
- Obstructive CAD was defined as a ⩾50% lumen narrowing.
- Conventional atherosclerosis risk factors were also evaluated.
Main Results:
- Lower BMD was associated with older age and lower BMI, but not significantly with diabetes, hypertension, dyslipidemia, or smoking.
- Prevalence of obstructive CAD and minimal CAD did not significantly differ between normal and low BMD groups (p=0.67 and p=0.52).
- Mean T-scores were not significantly different between patients with and without CAD.
Conclusions:
- The prevalence of low bone mineral density is not different in patients with or without obstructive coronary artery disease.
Background:
The association between low bone mineral density (BMD) and atherosclerosis is still unknown. In this study BMD assessed in patients with and without coronary artery atherosclerosis is determined by angiography.
Methods:
A total number of 123 consecutive patients referred for coronary angiography were evaluated by dual X-ray absorptiometry. Obstructive CAD was diagnosed when ⩾50% of lumen was narrowed. Conventional atherosclerosis risk factors were also assessed.
Results:
The mean age of the patients was 59 ± 8 years. There was frequency of 48.7% male. The prevalence of diabetes was 31.2%, hypertension 57%, dyslipoproteinaemia 51%, vitamin D deficiency 50% and history of smoking 80.8%. Coronary angiography was normal in 15 patients (12.6%) while 67 patients (55.5%) had obstructive CAD. DXA scan showed 25 patients (21%) with normal BMD, 39 patients (32.7%) with osteopenia, and 55 others (46.2%) with osteoporosis. Lower BMD results were significantly associated with older age and lower BMI but it was not associated significantly with diabetes, hypertension, lipids levels or smoking. Moreover the prevalence of obstructive CAD and minimal CAD differed between groups with normal and low bone density but this was not significant (p = 0.67 and 0.52, respectively). The mean T score comparison between patients with and without CAD was also not different.
Conclusions:
In patients with and without obstructive CAD the prevalence of low BMD results are not different.
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