Related Experiment Video
Updated: May 6, 2026
11:30
A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
Published on: June 2, 2022
1.8K
Bone mineral density and coronary atherosclerosis
Shokoofeh Hajsadeghi1, Mohamad-Ebrahim Khamseh, Bagher Larijani
1Department of Cardiology, Tehran University of Medical Sciences, Tehran, Iran.
Journal of the Saudi Heart Association
|October 23, 2013
Summary
Low bone mineral density (BMD) was not significantly associated with coronary artery disease (CAD) in patients undergoing angiography. The prevalence of low BMD did not differ between those with and without obstructive CAD.
Area of Science:
- Cardiovascular Medicine
- Endocrinology
- Radiology
Background:
- The relationship between low bone mineral density (BMD) and atherosclerosis remains unclear.
- This study investigates BMD in patients with and without coronary artery atherosclerosis.
Purpose of the Study:
- To determine if low bone mineral density is associated with coronary artery atherosclerosis.
- To compare BMD in patients with and without obstructive coronary artery disease (CAD).
Main Methods:
- 123 patients undergoing coronary angiography were assessed using dual X-ray absorptiometry (DXA).
- Obstructive CAD was defined as a ⩾50% lumen narrowing.
- Conventional atherosclerosis risk factors were also evaluated.
Main Results:
- Lower BMD was associated with older age and lower BMI, but not significantly with diabetes, hypertension, dyslipidemia, or smoking.
- Prevalence of obstructive CAD and minimal CAD did not significantly differ between normal and low BMD groups (p=0.67 and p=0.52).
- Mean T-scores were not significantly different between patients with and without CAD.
Conclusions:
- The prevalence of low bone mineral density is not different in patients with or without obstructive coronary artery disease.
Related Concept Videos
01:29Bone Disorders
8.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
8.0K
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
979
Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
979
01:30Coronary Artery Disease I: Introduction
1.8K
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.8K
01:27Atherosclerosis II: Clinical Manifestations and Diagnostic Tests
961
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
961
01:26Coronary Artery Disease II: Pathophysiology
1.1K
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
1.1K
01:30Coronary Artery Disease III: Clinical Manifestations
632
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
632