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Interkingdom complementation reveals structural conservation and functional divergence of 14-3-3 proteins

Marco Lalle1, Flora Leptourgidou, Serena Camerini

  • 1Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanità, Rome, Italy.

Plos One
|October 23, 2013
PubMed
Summary

The 14-3-3 protein from Giardia duodenalis is structurally similar to ancestral 14-3-3ε but functionally distinct. This suggests 14-3-3ε proteins are the evolutionary precursors to other 14-3-3 family members.

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