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Area of Science:

  • Cardiovascular Physiology
  • Endocrinology

Background:

  • The vascular endothelium regulates vascular tone and may influence orthostatic intolerance.
  • Sex steroid hormones are known to impact endothelial function.

Purpose of the Study:

  • To investigate the effect of orthostasis on endothelial function using a non-invasive method.
  • To examine gender differences and the influence of sex hormones on the endothelial response to orthostasis.

Main Methods:

  • Utilized EndoPAT®, a non-invasive device, to assess endothelial function.
  • Included males, females across menstrual cycle phases (follicular, luteal), and females on oral contraceptives.
  • Assessed endothelial function at baseline and after a 20-minute orthostatic challenge (active standing).

Main Results:

  • Endothelial function significantly increased following orthostasis in both females and males (p<0.001).
  • No significant differences were observed in the endothelial response between genders, menstrual cycle phases, or oral contraceptive use.

Conclusions:

  • Orthostasis elicits an increased vasodilatatory endothelial response in both sexes.
  • The impact of gender and sex hormones on this response appears limited.
  • Further research is needed to clarify the role of post-orthostasis endothelial function in orthostatic intolerance.