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Related Experiment Videos

Nematosomes in the human placenta.

C J Jones, C D Ockleford

    Placenta
    |July 1, 1985
    PubMed
    Summary

    The human placental nematosome, an electron-dense structure within cytotrophoblast cells, appears more frequently at full term. Its incidence is similar in normal and complicated pregnancies, suggesting a potential role in placental development.

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    Area of Science:

    • Human placental biology
    • Cellular ultrastructure
    • Reproductive medicine

    Background:

    • The human placenta plays a vital role in fetal development and maternal-fetal exchange.
    • Understanding the ultrastructural components of placental cells is crucial for identifying normal and pathological processes.
    • The nematosome (glomerular body) is an enigmatic structure observed within placental cells.

    Purpose of the Study:

    • To describe the ultrastructure of the human placental nematosome.
    • To investigate the occurrence and distribution of nematosomes in relation to gestational term and pregnancy complications.
    • To explore the potential relationship between nematosomes and centrioles.

    Main Methods:

    • Electron microscopy was used to examine placental tissue.
    • Ultrastructural analysis of nematosomes within cytotrophoblast cells.
    • Frequency and distribution analysis of nematosomes in placentae from normal and complicated pregnancies.

    Main Results:

    • Nematosomes are electron-dense aggregates (0.3-0.5 micron diameter) found within cytotrophoblast cells.
    • Observed configurations include spirals, rings, parallel arrays, random coils, and paracrystalline structures.
    • Nematosome frequency increases from the first and second trimesters to full term, with similar incidence across normal and pathological conditions.

    Conclusions:

    • Nematosomes are a common feature of full-term human placentae.
    • Their consistent incidence in both normal and complicated pregnancies suggests they are not a primary indicator of pathology.
    • Further morphometric analysis is recommended to elucidate nematosome structure, distribution, and cellular relationships.

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