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Ionic channels in epithelial cell membranes.

W Van Driessche, W Zeiske

    Physiological Reviews
    |October 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    This review highlights the similarities between potassium (K+) channels in excitable and epithelial membranes, suggesting related structures. It also details unique epithelial sodium (Na+) channels and intriguing hybrid channels with cross-reactivity.

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    Area of Science:

    • Ion channel biophysics
    • Epithelial transport
    • Cellular physiology

    Background:

    • Ionic channels in plasma membranes are crucial for cellular function.
    • Epithelial tissues exhibit diverse channel properties essential for transport.
    • Understanding channel structure and function aids in comprehending physiological processes.

    Purpose of the Study:

    • To review findings on ionic channels in epithelial tissues using patch clamping and current-noise analysis.
    • To compare properties of K+, Na+, and hybrid channels in various epithelia.
    • To investigate the structural and genetic relationships between different channel types.

    Main Methods:

    • Patch clamping for in situ ionic channel studies.
    • Current-noise analysis to investigate channel activity.

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  • Comparative analysis of channel properties across different species and tissues.

    • Main Results:

    • K+-specific channels in epithelia share properties with those in excitable membranes, including Ca2+-activated maxi K+ channels.
    • Epithelial Na+ channels are highly selective and chemically gated, differing from excitable Na+ channels.
    • Hybrid channels in tight epithelia show non-selective cation permeability and react to both Na+ and K+ channel blockers.

    Conclusions:

    • K+ channels in excitable and epithelial membranes appear closely related structurally.
    • Epithelial Na+ channels possess distinct characteristics compared to their excitable counterparts.
    • Hybrid channels present a unique model for exploring the relationship and potential interconversion of Na+ and K+ channels.