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snOPY: a small nucleolar RNA orthological gene database.

Maki Yoshihama, Akihiro Nakao, Naoya Kenmochi1

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Summary

The snoRNA orthological gene database (snOPY) aids in studying RNA modifications and small nucleolar RNA (snoRNA) gene evolution. This resource provides comprehensive data on snoRNAs and their orthologues across species.

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Area of Science:

  • Molecular Biology
  • Genomics
  • Bioinformatics

Background:

  • Small nucleolar RNAs (snoRNAs) are non-coding RNAs crucial for modifying ribosomal RNAs (rRNAs) and small nuclear RNAs (snRNAs).
  • The functional roles of post-transcriptional modifications in non-coding RNAs are not fully understood.
  • Investigating snoRNA gene evolution and function requires accessible comparative genomic data.

Purpose of the Study:

  • To introduce the snoRNA orthological gene database (snOPY) as a novel resource.
  • To facilitate the study of RNA modifications and snoRNA gene evolution.
  • To provide a user-friendly platform for accessing comprehensive snoRNA-related data.

Main Methods:

  • Development of a specialized database, snOPY, for snoRNA research.
  • Integration of data on snoRNAs, their gene loci, and target RNAs.
  • Inclusion of orthologous snoRNA gene data from multiple species.

Main Results:

  • The snOPY database contains 13,770 snoRNA genes, 10,345 gene loci, and 133 target RNAs.
  • Orthologue data enables evolutionary analysis of snoRNA genes.
  • A simple web interface with internal links ensures efficient data retrieval.

Conclusions:

  • snOPY serves as a valuable database for small nucleolar RNAs and their orthologues.
  • The database supports research into RNA modifications and the evolutionary history of snoRNA genes.
  • snOPY is freely accessible online, promoting broader scientific inquiry.