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Stem cell therapy in amyotrophic lateral sclerosis.

Rokhsareh Meamar1, Mohammad Hossein Nasr-Esfahani, Seyed Ali Mousavi

  • 1Department of Medical Science, Najafabad Branch, Islamic Azad University, Isfahan, Iran.

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
|October 24, 2013
PubMed
Summary

Stem cell therapy shows promise for treating amyotrophic lateral sclerosis (ALS), a motor neuron disease. This review explores various stem cell methods and their outcomes in ALS patients, offering potential therapeutic strategies.

Keywords:
Amyotrophic lateral sclerosisCell therapyClinical trialMotor neuronStem cellTransplantation

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Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Neurology

Background:

  • Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder affecting motor neurons, leading to muscle atrophy and weakness.
  • The exact causes of ALS are not fully understood, despite various proposed mechanisms.
  • Current treatments for ALS are limited, highlighting the need for novel therapeutic approaches.

Purpose of the Study:

  • To review current stem cell therapy methods for amyotrophic lateral sclerosis (ALS).
  • To discuss the efficacy of different cell types and administration routes in ALS treatment.
  • To evaluate the potential of stem cell therapy as a promising strategy for ALS.

Main Methods:

  • Literature review of studies on stem cell therapy in ALS patients.
  • Analysis of different stem cell types used, including mesenchymal stem cells, neural stem cells, and induced pluripotent stem cells.
  • Examination of various administration routes, such as intrathecal and intravenous delivery.

Main Results:

  • Stem cell therapy has demonstrated potential in preclinical models and early-phase clinical trials for ALS.
  • Different cell types exhibit varying degrees of neuroprotection and functional recovery.
  • The route of administration can influence the distribution and efficacy of transplanted cells.

Conclusions:

  • Stem cell therapy represents a promising therapeutic avenue for amyotrophic lateral sclerosis (ALS).
  • Further research is needed to optimize cell types, delivery methods, and long-term outcomes.
  • Stem cell interventions may offer a novel strategy to combat the progression of this devastating motor neuron disease.