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Updated: May 6, 2026
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Determination of Inorganic Arsenic in a Wide Range of Food Matrices using Hydride Generation - Atomic Absorption Spectrometry.
Published on: September 1, 2017
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[Study on MSO/GO-based determination method for trace amount of aqueous Hg2+]
1Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine, Wenzhou Medical Univesity, Wenzhou, Zhejiang Province 325035, China.
Summary
A novel nanobiosensor using mercury-specific oligonucleotide (MSO) probes and graphene oxide (GO) offers a highly sensitive method for detecting aqueous mercury ions (Hg2+). This reusable sensor demonstrates excellent specificity and accuracy for environmental monitoring.
Area of Science:
- Nanotechnology
- Biosensors
- Environmental Chemistry
Context:
- Mercury ions (Hg2+) are significant environmental pollutants.
- Accurate and sensitive detection methods are crucial for monitoring Hg2+ levels.
- Graphene oxide (GO) offers a versatile platform for nanomaterial-based sensors.
Purpose:
- To develop a highly sensitive fluorometric nanobiosensor for aqueous Hg2+ determination.
- To utilize optimized mercury-specific oligonucleotide (MSO) probes and GO for enhanced detection.
- To establish a convenient, specific, accurate, and reusable sensor for trace Hg2+ analysis.
Summary:
- A nanobiosensor was constructed by immobilizing MSO probes (FAM-MSO(1) and MSO(2)) onto GO via non-covalent bonding.
- Hg2+ detection relies on the T-Hg2+-T configuration, causing desorption of FAM-MSO(1) from GO and restoring fluorescence.
- The sensor achieved a limit of detection of 10 pmol/L with high specificity and reusability.
Impact:
- Provides a sensitive and specific method for detecting trace amounts of Hg2+ in aqueous solutions.
- The MSO/GO-based nanobiosensor is convenient, accurate, and reusable, suitable for environmental monitoring.
- Demonstrates the potential of oligonucleotide-functionalized nanomaterials in developing advanced analytical tools.
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