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Plasma leptin and adiponectin concentrations correlate with cardiometabolic risk and systemic inflammation in

Dimitrios A Stakos, Helena I Papaioannou, Iliana Angelidou

    Journal of Pediatric Endocrinology & Metabolism : JPEM
    |October 24, 2013
    PubMed

    Insights

    Plasma leptin and adiponectin levels in non-obese children are linked to cardiometabolic risk factors. These adipocytokines may help identify children with higher health risks, even without obesity.

    Area of Science:

    • Pediatric Endocrinology
    • Metabolic Syndrome Research
    • Cardiovascular Risk Assessment

    Background:

    • Plasma adipocytokines (hormones secreted by adipose tissue) are linked to metabolic health and cardiovascular disease risk in obese children.
    • Understanding these associations in non-obese children is crucial for early risk identification.

    Purpose of the Study:

    • To investigate the relationship between plasma leptin and adiponectin concentrations and cardiometabolic risk markers in healthy, non-obese children.
    • To assess the association with systemic inflammation indicators.

    Main Methods:

    • Study included 170 healthy, non-obese children (mean age 10 years).
    • Measurements included body mass index (BMI), plasma leptin and adiponectin, lipid profile, fasting glucose, and high-sensitivity C-reactive protein (hsCRP).

    Main Results:

    • Leptin correlated positively with hsCRP and fasting glucose; adiponectin correlated negatively with hsCRP and positively with HDL cholesterol, after adjusting for BMI.
    • A higher leptin/adiponectin ratio was associated with increased BMI, blood pressure, hsCRP, triglycerides, fasting glucose, and lower HDL cholesterol.

    Conclusions:

    • Plasma leptin and adiponectin alterations can help identify non-obese children with unfavorable cardiometabolic risk profiles, independent of BMI.
    • These adipocytokines may serve as biomarkers for early detection of metabolic dysfunction in children.
    Abstract

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