Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Addressing pandemic-wide systematic errors in the SARS-CoV-2 phylogeny.

Nature methods·2026
Same author

Exploring perceptual disparities: A study on the level of understanding of colorectal cancer care among patients and healthcare professionals.

International journal of colorectal disease·2026
Same author

Relational Supervision and Intellectual Candour: How to Create Trust?

The clinical teacher·2025
Same author

Real-world effectiveness of palbociclib plus hormone treatment and its impact on patient quality of life: a plain language summary of findings from POLARIS.

Future oncology (London, England)·2025
Same author

A First-In-Human Study of the SUMOylation Inhibitor Subasumstat in Patients with Advanced/Metastatic Solid Tumors or Relapsed/Refractory Hematologic Malignancies.

Cancer research communications·2025
Same author

Expansion of the functional genomics GRACE library reveals genes relevant for temperature-dependent fitness in Candida albicans.

PLoS biology·2025

Related Experiment Video

Updated: May 6, 2026

Delivery of Therapeutic siRNA to the CNS Using Cationic and Anionic Liposomes
10:33

Delivery of Therapeutic siRNA to the CNS Using Cationic and Anionic Liposomes

Published on: July 23, 2016

10.4K

Delivery materials for siRNA therapeutics.

Rosemary Kanasty1, Joseph Robert Dorkin, Arturo Vegas

  • 11] Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA [2] David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.

Nature Materials
|October 24, 2013
PubMed
Summary

Developing effective delivery materials is crucial for realizing the therapeutic potential of RNA interference (RNAi) to silence genes. This review explores advanced delivery systems like lipid nanoparticles and siRNA conjugates designed to overcome biological barriers for targeted gene silencing therapies.

More Related Videos

Drug-induced Sensitization of Adenylyl Cyclase: Assay Streamlining and Miniaturization for Small Molecule and siRNA Screening Applications
09:39

Drug-induced Sensitization of Adenylyl Cyclase: Assay Streamlining and Miniaturization for Small Molecule and siRNA Screening Applications

Published on: January 27, 2014

11.8K
MISSION esiRNA for RNAi Screening in Mammalian Cells
15:31

MISSION esiRNA for RNAi Screening in Mammalian Cells

Published on: May 12, 2010

18.8K

Related Experiment Videos

Last Updated: May 6, 2026

Delivery of Therapeutic siRNA to the CNS Using Cationic and Anionic Liposomes
10:33

Delivery of Therapeutic siRNA to the CNS Using Cationic and Anionic Liposomes

Published on: July 23, 2016

10.4K
Drug-induced Sensitization of Adenylyl Cyclase: Assay Streamlining and Miniaturization for Small Molecule and siRNA Screening Applications
09:39

Drug-induced Sensitization of Adenylyl Cyclase: Assay Streamlining and Miniaturization for Small Molecule and siRNA Screening Applications

Published on: January 27, 2014

11.8K
MISSION esiRNA for RNAi Screening in Mammalian Cells
15:31

MISSION esiRNA for RNAi Screening in Mammalian Cells

Published on: May 12, 2010

18.8K

Area of Science:

  • Biotechnology
  • Molecular Biology
  • Drug Delivery Systems

Background:

  • RNA interference (RNAi) offers a promising therapeutic strategy for reversible gene silencing.
  • Effective delivery of short interfering RNA (siRNA) to target tissues is a major hurdle for clinical applications.
  • Overcoming biological barriers is essential for successful siRNA-based therapies.

Purpose of the Study:

  • To introduce the biological challenges associated with siRNA delivery.
  • To discuss the design principles of advanced siRNA delivery systems.
  • To provide insights for the development of future delivery materials.

Main Methods:

  • Review of current literature on siRNA delivery systems.
  • Analysis of clinically advanced delivery platforms, including lipid nanoparticles and siRNA conjugates.
  • Discussion of design strategies to overcome biological delivery challenges.

Main Results:

  • Identification of key biological challenges in siRNA delivery.
  • Detailed examination of lipid nanoparticles and siRNA conjugates as effective delivery systems.
  • Highlighting the diverse approaches employed by various delivery systems.

Conclusions:

  • Advanced delivery systems are critical for the clinical translation of RNAi therapeutics.
  • Lipid nanoparticles and siRNA conjugates represent leading strategies for overcoming siRNA delivery obstacles.
  • Understanding current systems offers valuable guidance for future innovation in siRNA delivery material design.