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Updated: May 6, 2026
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An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney
Published on: November 1, 2018
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[Rapid progressive glomerulonephritis as a nephrological emergency--case 8/2013]
Otto Tschritter1, Maike Büttner, Peter Weyrich
1Medizinische Klinik, Universitätsklinikum Tübingen.
Deutsche Medizinische Wochenschrift (1946)
|October 24, 2013
Summary
Rapid-progressive glomerulonephritis is a medical emergency. This case highlights IgA nephropathy presenting with pneumonia and acute kidney injury, requiring immunosuppression and dialysis.
Area of Science:
- Nephrology
- Pulmonology
- Immunology
Background:
- Acute kidney injury (AKI) and respiratory failure can be multifactorial.
- IgA nephropathy is a common primary glomerulonephritis, but can present with severe systemic manifestations.
Observation:
- A 53-year-old female presented with fever, dyspnea, arthralgias, diarrhea, and anuria.
- Respiratory deterioration led to hospitalization, revealing pneumonia and pulmonary congestion.
- Active urine sediment and hyperechoic renal parenchyma indicated kidney involvement.
Findings:
- Histological examination confirmed extracapillary proliferative IgA glomerulonephritis.
- Pneumonia was attributed to pulmonary congestion and influenza infection.
- The patient required hemodialysis and immunosuppressive therapy with cyclophosphamide.
Implications:
- Rapid-progressive glomerulonephritis is a critical condition necessitating prompt diagnosis and management.
- Early intervention is crucial to prevent irreversible kidney damage and multi-organ dysfunction.
- This case underscores the importance of considering glomerulonephritis in patients with unexplained AKI and systemic symptoms.
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