Skinomics: past, present and future for diagnostic microarray studies in dermatology.
1The R.O. Perelman Department of Dermatology, Department of Biochemistry and Molecular Pharmacology, the NYU Cancer Institute, NYU Langone Medical Center, NYU School of Medicine, 455 First Avenue, P.H.B. Room 874, New York NY 10016, USA.
Expert Review of Molecular Diagnostics
|October 25, 2013
Summary
Skin
Area of Science:
- Dermatology and 'omics' research.
Background:
- The skin is an accessible organ for 'omics' analysis, with early adoption in dermatology.
- Microarrays have been instrumental in identifying disease markers and transcriptional changes in skin conditions like melanoma and psoriasis.
Purpose of the Study:
- To highlight the advancements and potential of 'omics' technologies in dermatology.
- To showcase the application of microarrays in understanding skin diseases and developing personalized medicine.
Main Methods:
- Utilizing microarray technology for analyzing skin biopsies and tape strips.
- Investigating transcriptional changes in epidermal keratinocytes and stem cells.
- Exploring the human skin microbiome.
Main Results:
- Microarrays have successfully mapped psoriasis susceptibility loci and identified transcriptional changes in psoriasis.
- Characterization of epidermal differentiation genes and their expression in stem cells.
- Discovery of the human skin microbiome offers new research avenues.
Conclusions:
- Non-invasive skin sampling methods like tape stripping are advancing dermatology.
- 'Omics' techniques are paving the way for personalized medicine in dermatology.
- Continued research into skin biology, including the microbiome, holds significant medical potential.
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