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Programmed death-1 expression in cutaneous B-cell lymphoma.

Fatma Çetinözman1, Lianne Koens, Patty M Jansen

  • 1Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.

Journal of Cutaneous Pathology
|October 25, 2013
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Summary
This summary is machine-generated.

Programmed death-1 (PD-1) is rarely found on neoplastic B cells in cutaneous B-cell lymphomas (CBCL). However, a high percentage of PD-1 positive T cells supports a diagnosis of primary cutaneous follicle center lymphoma (PCFCL).

Keywords:
PD-1cutaneous B-cell lymphomafollicular helper T cellnon-Hodgkin lymphoma

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Area of Science:

  • Immunology
  • Dermatology
  • Oncology

Background:

  • Programmed death-1 (PD-1) positive T cells have prognostic significance in nodal B-cell lymphomas.
  • Limited data exist on PD-1 expression in cutaneous B-cell lymphoma (CBCL).
  • This study investigates PD-1 expression on neoplastic B cells and reactive T cells in primary CBCL skin sections.

Purpose of the Study:

  • To determine the expression and distribution of PD-1 on neoplastic B cells and reactive T cells in primary CBCL.
  • To assess the diagnostic utility of PD-1 expression in differentiating CBCL subtypes.

Main Methods:

  • Immunohistochemical staining was employed to investigate PD-1 expression.
  • Skin biopsies from 10 primary cutaneous marginal zone lymphoma (PCMZL), 18 primary cutaneous follicle center lymphoma (PCFCL), and 12 primary cutaneous diffuse large B-cell lymphoma-leg type (PCDLBCL-LT) patients were analyzed.

Main Results:

  • Neoplastic B cells were PD-1 negative in all but two PCDLBCL-LT cases.
  • The frequency of PD-1 positive T cells was significantly higher in PCFCL (20% of infiltrating cells, 60% of CD3+ T cells) compared to PCMZL (10%, 20%) and PCDLBCL-LT (3%, 15%).

Conclusions:

  • PD-1 expression is rare on neoplastic B cells in CBCL.
  • Elevated percentages of PD-1 positive T cells, especially outside germinal centers, are indicative of PCFCL.