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Skin viscoelasticity during hormone replacement therapy for climacteric ageing
G E Piérard1, T Hermanns-Lê1, P Paquet1
1Laboratory of Skin Bioengineering and Imaging (LABIC), Department of Clinical Sciences, B23, University of Liège, B-4000, Liège, Belgium.
Hormone replacement therapy (HRT) may help counteract menopause-related skin changes, but biological elasticity decreases without HRT. Further research into treatments for menopausal skin is suggested.
Area of Science:
- Dermatology
- Gerontology
- Endocrinology
Background:
- Climacteric aging, centered by perimenopause, causes skin atrophy and changes in dermal connective tissue viscoelasticity.
- Hormone replacement therapy (HRT) is used by some women to manage menopausal symptoms like osteoporosis and vasomotor instability.
Purpose of the Study:
- To investigate the corrective effects of HRT on functional damage in dermal tensile strength.
- To assess HRT's impact on skin viscoelasticity during menopausal aging.
Main Methods:
- The study included 200 healthy Caucasian women.
- In vivo skin viscoelasticity was measured using the suction method.
Main Results:
- Skin distensibility and hysteresis increased during menopause, irrespective of HRT.
- Biological elasticity significantly decreased in women not receiving HRT.
Conclusions:
- Menopausal skin viscoelasticity may be improved by certain drugs and cosmetic treatments.
- HRT appears to have a role in maintaining skin elasticity during menopause.
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