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Updated: May 6, 2026
05:16
Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage
Published on: August 4, 2021
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[Annexins and recurrent pregnancy loss]
Sebastián Udry1, Federico Aranda, Omar Latino
1Consultorio de enfermedades autoinmunes trombofílicas y embarazo, Hospital Carlos G. Durand, Buenos Aires, Argentina.
Medicina
|October 25, 2013
Summary
Recurrent Pregnancy Loss (RPL) may be linked to reduced expression of the annexin A5 (ANXA5) protein. The ANXA5 M2 haplotype is associated with decreased ANXA5 levels and pregnancy complications.
Area of Science:
- Reproductive immunology
- Genetics
- Obstetrics
Context:
- Recurrent Pregnancy Loss (RPL) impacts women's health, with 50% of cases being idiopathic.
- Annexin A5 (ANXA5) is a trophoblastic protein crucial for pregnancy with immunomodulatory and anticoagulant functions.
- Genetic variations in ANXA5 may affect its expression and function during pregnancy.
Purpose:
- To review the structure, function, and genetic expression of ANXA5.
- To explore the potential role of ANXA5 genetic variations, specifically the M2 haplotype, in the etiology of RPL.
Summary:
- ANXA5, a key protein at the placental level, plays vital roles in pregnancy.
- The ANXA5 M2 haplotype is linked to decreased ANXA5 expression.
- This decreased expression is associated with RPL, fetal growth restriction, low birth weight, preeclampsia, and maternal thromboembolism.
Impact:
- Provides insights into the idiopathic causes of RPL.
- Highlights ANXA5 as a potential diagnostic marker or therapeutic target for pregnancy complications.
- Enhances understanding of the genetic basis of reproductive disorders.
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