Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

2.5K
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
2.5K
Inflammation01:38

Inflammation

46.8K
Overview
46.8K
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

961
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
961
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

1.1K
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Localized Delivery of Amifostine Enhances Salivary Gland Radioprotection.

Journal of dental research·2018
Same author

Analysis of the non-Markov parameter in continuous-time signal processing.

Physical review. E, Statistical, nonlinear, and soft matter physics·2014
Same author

Theoretical & experimental analysis of the Non Markov Parameter to detect low frequency synchronisation in time series analysis.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2012
Same author

Lipoic acid attenuates innate immune infiltration and activation in the visceral adipose tissue of obese insulin resistant mice.

Lipids·2011
Same author

Regulation of adipose triglyceride lipase by rosiglitazone.

Diabetes, obesity & metabolism·2008
Same author

[Seroepidemiological studies on the immunization of the population against species of the genus Bordetella in 1996-1997].

Bacteriologia, virusologia, parazitologia, epidemiologia (Bucharest, Romania : 1990)·1999

Related Experiment Video

Updated: May 6, 2026

Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice
07:36

Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice

Published on: September 26, 2018

9.7K

Renin-sensitive microRNAs correlate with atherosclerosis plaque progression.

J Deiuliis1, G Mihai1, J Zhang2

  • 1Davis Heart & Lung Research Institute, The Ohio State University College of Medicine, Columbus, OH, USA.

Journal of Human Hypertension
|October 25, 2013
PubMed
Summary

Direct renin inhibition with Aliskiren altered microRNA expression in patients with cardiovascular disease. Specific microRNAs (miRs) downregulated by Aliskiren correlated with atherosclerosis burden, suggesting a role in RAAS pathway adaptation.

More Related Videos

Single Nuclei Isolation from Coronary Endarterectomy Tissue of Coronary Artery Bypass Graft Patients
09:09

Single Nuclei Isolation from Coronary Endarterectomy Tissue of Coronary Artery Bypass Graft Patients

Published on: April 3, 2026

274
Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus
06:43

Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus

Published on: December 7, 2013

14.0K

Related Experiment Videos

Last Updated: May 6, 2026

Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice
07:36

Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice

Published on: September 26, 2018

9.7K
Single Nuclei Isolation from Coronary Endarterectomy Tissue of Coronary Artery Bypass Graft Patients
09:09

Single Nuclei Isolation from Coronary Endarterectomy Tissue of Coronary Artery Bypass Graft Patients

Published on: April 3, 2026

274
Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus
06:43

Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus

Published on: December 7, 2013

14.0K

Area of Science:

  • Cardiovascular Medicine
  • Molecular Biology
  • Pharmacology

Background:

  • Renin-angiotensin-aldosterone system (RAAS) inhibition trials for atherosclerosis have yielded mixed results.
  • MicroRNAs (miRs) are implicated in atherosclerosis pathways, including RAAS.
  • The effect of direct renin antagonism on miR regulation in atherosclerosis is not well understood.

Purpose of the Study:

  • To investigate the impact of the direct renin antagonist Aliskiren on microRNA expression in patients with established cardiovascular disease.
  • To determine if changes in specific miRs correlate with atherosclerosis progression during renin inhibition.

Main Methods:

  • A prospective, randomized, double-blind, placebo-controlled trial (NCT01417104) involving patients with established cardiovascular disease.
  • Assessment of thoracic and abdominal aorta atherosclerosis using 3D dark-blood MRI at baseline and study completion.
  • Analysis of peripheral blood mononuclear cell (PBMC) microRNA expression arrays before and after 12 weeks of Aliskiren or placebo treatment.

Main Results:

  • Aliskiren treatment led to significant downregulation of hsa-miR-106b-5p, hsa-miR-27a-3p, and hsa-miR-18b-5p.
  • Baseline expression levels of these downregulated miRs positively correlated with normalized total aortic wall volume in the Aliskiren group.
  • Correlations were observed for miR-106b (R=0.62), miR-27a (R=0.63), and miR-18b (R=0.77), all with P<0.05.

Conclusions:

  • Aliskiren treatment induces differential microRNA expression changes in patients with cardiovascular disease.
  • Hsa-miR-106b-5p, hsa-miR-27a-3p, and hsa-miR-18b-5p may serve as biomarkers for pathway-specific adaptations to renin inhibition in atherosclerosis.
  • These findings contribute to understanding the molecular mechanisms linking RAAS inhibition and atherosclerosis.