Related Experiment Video

Updated: May 6, 2026

Highly Sensitive Assay for Measurement of Arenavirus-cell Attachment
08:34

Highly Sensitive Assay for Measurement of Arenavirus-cell Attachment

Published on: March 2, 2016

7.1K

[Filoviruses]

Ayato Takada1

  • 1Hokkaido University Research Center for Zoonosis Control.

Uirusu
|October 25, 2013
PubMed

Insights

Filoviruses, like Ebola and Marburg viruses, cause severe hemorrhagic fever. This review covers recent advances in filovirus biology, host interactions, and epidemiology, highlighting the need for effective treatments.

Area of Science:

  • Virology
  • Infectious Diseases
  • Molecular Biology

Context:

  • Filoviruses, including Ebola and Marburg viruses, are significant public health threats causing severe hemorrhagic fevers.
  • Current medical interventions for filovirus diseases lack commercial availability, necessitating further research.
  • Recent scientific discoveries have expanded the understanding of filovirus biology and epidemiology.

Purpose:

  • To review fundamental aspects of filovirus biology.
  • To discuss the latest research on filovirus protein functions and host-pathogen interactions.
  • To provide insights into the epidemiology of filovirus hemorrhagic fevers based on new ecological findings.

Summary:

  • This article synthesizes current knowledge on filovirus biology, focusing on protein functions and host-virus interactions during replication.
  • It incorporates recent ecological findings, such as nonprimate animal infections and the identification of a novel European filovirus, to illuminate disease epidemiology.
  • The review emphasizes the ongoing need for effective prophylaxis and treatment strategies against these dangerous pathogens.

Impact:

  • Enhances understanding of filovirus pathogenesis and replication mechanisms.
  • Provides a comprehensive overview of current filovirus research for scientists and public health officials.
  • Informs the development of novel diagnostic, therapeutic, and prophylactic strategies against filovirus infections.

More Related Videos

Modeling The Lifecycle Of Ebola Virus Under Biosafety Level 2 Conditions With Virus-like Particles Containing Tetracistronic Minigenomes10:11

Modeling The Lifecycle Of Ebola Virus Under Biosafety Level 2 Conditions With Virus-like Particles Containing Tetracistronic Minigenomes

Published on: September 27, 2014

38.3K
Bacterial Artificial Chromosomes: A Functional Genomics Tool for the Study of Positive-strand RNA Viruses12:20

Bacterial Artificial Chromosomes: A Functional Genomics Tool for the Study of Positive-strand RNA Viruses

Published on: December 29, 2015

22.2K

Related Concept Videos

Viruses with RNA Genomes01:29

Viruses with RNA Genomes

RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...
1.5K
Retroviruses02:33

Retroviruses

Retroviruses and retrotransposons both insert copies of their genetic elements into the genome of the host cell. Thus, the viral genes are passed on when the host genome is replicated or translated. A typical retroviral DNA sequence contains 3-4 genes that encode the different proteins required for its structural assembly and function as a molecular parasite. This DNA is transcribed into a single mRNA, which is very similar in structure to conventional mRNAs, i.e., it is capped at the 5’...
12.3K
What are Viruses?00:50

What are Viruses?

Overview
109.9K
Size and Structure of Viral Genomes01:26

Size and Structure of Viral Genomes

Viral genomes exhibit remarkable diversity in size, structure, and composition, influencing their replication strategies and interactions with host cells. These genomes consist of either DNA or RNA and may be linear or circular. Additionally, they can be single-stranded or double-stranded, with each configuration affecting how the virus propagates within a host. RNA viruses, for instance, generally have smaller genomes than DNA viruses, a factor that contributes to their high mutation rates and...
1.2K
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
108
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion...
28