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Related Experiment Videos

A decrease in clonus amplitude by topical anesthesia.

W J Mills, R S Pozos

    Electroencephalography and Clinical Neurophysiology
    |December 1, 1985
    PubMed
    Summary
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    Topical anesthetic significantly reduced the amplitude of pathological clonus, physiological clonus, and physiological action tremor. This non-invasive method shows potential for managing involuntary oscillations like tremors and clonus.

    Area of Science:

    • Neurology
    • Dermatology
    • Biophysics

    Background:

    • Involuntary oscillations such as pathological clonus, physiological clonus, and physiological action tremor affect motor control.
    • Understanding the mechanisms and potential non-invasive treatments for these oscillations is crucial for clinical applications.

    Purpose of the Study:

    • To investigate the effects of skin desensitization using topical anesthetic on the amplitude and frequency of three types of involuntary ankle oscillations.
    • To explore the potential of topical anesthetics as a non-invasive therapeutic strategy.

    Main Methods:

    • Topical anesthetic was applied to the skin of the leg, ankle, and proximal foot.
    • The study assessed changes in pathological clonus (in spinal cord patients), physiological clonus (in normal subjects post-exercise), and physiological action tremor (in normal subjects during voluntary movement).

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    Main Results:

    • A significant decrease in the amplitude of all three oscillations was observed after topical anesthetic application.
    • No significant changes in the frequency of these oscillations were detected.
    • Pathological clonus amplitude was profoundly reduced, preventing initiation in patients for up to 30 minutes.

    Conclusions:

    • Topical anesthetic effectively attenuates the amplitude of pathological clonus, physiological clonus, and physiological action tremor.
    • The findings suggest a potential common underlying mechanism for these oscillations.
    • Topical anesthetic offers a promising non-invasive approach for managing tremors and clonus.