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Antilupus activity of copper (II)
Experimental Pathology
|January 1, 1985
Summary
Copper supplementation reduced the incidence of LE cells and increased superoxide dismutase activity in rats with hydralazine-induced collagen-like syndrome.
Area of Science:
- Toxicology and Pharmacology
- Biochemistry and Molecular Biology
Background:
- Hydralazine administration in rats can induce a collagen-like syndrome, mimicking autoimmune conditions.
- Copper is an essential cofactor for antioxidant enzymes, including superoxide dismutase.
Purpose of the Study:
- To investigate the effect of copper supplementation on hydralazine-induced collagen-like syndrome in rats.
- To assess the impact of copper on serum copper levels, LE cell formation, and superoxide dismutase activity.
Main Methods:
- Rats were administered hydralazine orally for 5 months to induce collagen-like syndrome.
- A subgroup received a copper-supplemented diet (60 µg copper/g pellet) for the final month.
- Serum copper concentration, presence of LE cells, and erythrocyte superoxide dismutase activity were measured.
Main Results:
- Copper supplementation significantly reduced the occurrence of LE cells (40% vs. 75% in control rats).
- Activity of superoxide dismutase, a copper-dependent antioxidant enzyme, was significantly higher in copper-supplemented rats.
- Serum copper levels were noted to decrease in rats with hydralazine-induced syndrome.
Conclusions:
- Copper supplementation may ameliorate hydralazine-induced collagen-like syndrome in rats.
- Enhanced antioxidant capacity, evidenced by increased superoxide dismutase activity, may contribute to the protective effects of copper.