Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Calcium diffusion models and transmitter release in neurons.

R S Zucker

    Federation Proceedings
    |December 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Presynaptic effectors contributing to cAMP-induced synaptic potentiation in Drosophila.

    Journal of neurobiology·2005
    Same author

    Roles for mitochondrial and reverse mode Na+/Ca2+ exchange and the plasmalemma Ca2+ ATPase in post-tetanic potentiation at crayfish neuromuscular junctions.

    The Journal of neuroscience : the official journal of the Society for Neuroscience·2001
    Same author

    Phosphorylation and local presynaptic protein synthesis in calcium- and calcineurin-dependent induction of crayfish long-term facilitation.

    Neuron·2001
    Same author

    Presynaptic target of Ca2+ action on neuropeptide and acetylcholine release in Aplysia californica.

    The Journal of physiology·2001
    Same author

    Photolysis-induced suppression of inhibition in rat hippocampal CA1 pyramidal neurons.

    The Journal of physiology·2001
    Same author

    Increased Ca2+ buffering enhances Ca2+-dependent process.

    The Journal of physiology·2001

    Calcium influx into neurons is diluted by diffusion, making average concentrations poor indicators of cell activity. Mathematical models of calcium diffusion are crucial for understanding neuron function and calcium-dependent processes.

    Area of Science:

    • Neuroscience
    • Cell Biology
    • Biophysics

    Background:

    • Calcium ions (Ca2+) are critical intracellular messengers in neurons.
    • Calcium entry and subsequent diffusion influence various cellular processes.
    • Simple average cytoplasmic Ca2+ levels do not fully represent localized Ca2+ dynamics.

    Purpose of the Study:

    • To highlight the limitations of average cytoplasmic calcium concentration as a predictor of neuronal activity.
    • To emphasize the importance of calcium diffusion dynamics in neuronal function.
    • To underscore the utility of mathematical modeling in understanding calcium signaling.

    Main Methods:

    • Analysis of calcium diffusion within neuronal compartments.
    • Application of diffusion equation solutions with specific boundary conditions.

    Related Experiment Videos

  • Quantitative modeling of intracellular calcium dynamics.

    • Main Results:

    • Calcium concentration decreases with inward diffusion from the neuronal surface.
    • Localized calcium levels, not average concentrations, dictate specific cellular events.
    • Mathematical models provide a framework for interpreting complex calcium signals.

    Conclusions:

    • Understanding calcium dynamics requires considering diffusion and spatial distribution.
    • Computational models are essential tools for quantitative analysis of neuronal calcium signaling.
    • Accurate prediction of calcium-dependent neuronal processes relies on diffusion modeling.