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Reversible slurred speech related to capecitabine and lapatinib combination in patients with breast cancer

Hasan Mutlu1, Abdullah Büyükçelik2, Zeki Akça3

  • 1Department of Medical Oncology, Acibadem Kayseri Hospital, Kayseri, Turkey doktorhasanmutlu@gmail.com.

Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners
|October 25, 2013
PubMed

Capecitabine plus lapatinib combination is an effective chemotherapy regimen in patients with advanced breast cancer. Neurological adverse effects secondary to this regimen were reported rarely in literature. A woman with breast cancer presented with complaints of slurred speech while using the capecitabine and lapatinib combination. Her major complaint was slurred speech. No other radiologic or laboratory disorders were detected in the patient. Slurred speech improved one week after the capecitabine and lapatinib combination was discontinued without any further intervention.

Keywords:
Capecitabineadverse eventbreast cancerlapatinibspeech

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