Delineating the membrane-disrupting and seeding properties of the TDP-43 amyloidogenic core
Gerard Chun-Hao Liu1, Bryan Po-Wen Chen, Nancy Ting-Juan Ye
1Institute of Chemistry, Academia Sinica, No. 128, Sec. 2, Academia Road, Nankang, Taipei 115, Taiwan. jthuang@chem.sinica.edu.tw.
Chemical Communications (Cambridge, England)
|October 25, 2013
Abstract:
The amyloidogenic core in the TAR DNA-binding protein (TDP-43) C-terminal fragment has been characterized with its chemical, biochemical, and structural properties delineated. Various properties of the core sequence, including membrane impairment ability and the seeding effect, have also been studied.
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