Immunocytochemical detection of ricin. I. Preliminary immunofluorescence studies

Ricin injected into rat muscle in vivo can be localized within a few hours using routine immunofluorescence techniques on formalin-fixed tissues. However, the level of sensitivity decreases with increase in size of animal injected, time after administration and decrease in dose given. These findings are discussed in relation to the known chemistry and subcellular mode of action of ricin.