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Impact of virus clearance for the development of hemorrhagic stroke in chronic hepatitis C

Yasuji Arase1, Mariko Kobayashi, Yusuke Kawamura

  • 1Department of Hepatology and Okinaka Memorial Institute for Medical Research, Toranomon Hospital, Tokyo, Japan; Department of Health Management Center, Toranomon Hospital, Tokyo, Japan; Department of Third Internal Medicine, University of Yamanashi, Yamanashi, Japan.

Journal of Medical Virology
|October 25, 2013
PubMed

Insights

Hepatitis C virus (HCV) clearance after interferon (IFN) therapy significantly reduces the risk of intracerebral hemorrhagic stroke. This protective effect is particularly pronounced in patients with liver cirrhosis, lowering stroke risk by approximately 75%.

Area of Science:

  • Hepatology
  • Neurology
  • Infectious Diseases

Background:

  • Hepatitis C virus (HCV) infection poses significant health risks.
  • Interferon (IFN) therapy has been used to treat HCV.
  • Intracerebral hemorrhagic stroke is a serious complication.

Purpose of the Study:

  • To assess the incidence of intracerebral hemorrhagic stroke after IFN therapy termination in HCV patients.
  • To identify predictive factors for intracerebral hemorrhagic stroke post-IFN treatment.
  • To evaluate the impact of HCV clearance on stroke development.

Main Methods:

  • Retrospective cohort study of 4,649 HCV-positive patients treated with IFN.
  • Kaplan-Meier method and Cox proportional hazard model for analysis.
  • Mean observation period of 8.0 years.

Main Results:

  • 28 patients developed intracerebral hemorrhagic stroke.
  • Cumulative incidence was 1.7% at 15 years.
  • Predictive factors included age, hypertension, liver cirrhosis, and HCV non-clearance.
  • HCV clearance reduced stroke risk by 75% in cirrhotic patients.

Conclusions:

  • HCV clearance is associated with a reduced incidence of intracerebral hemorrhagic stroke.
  • Liver cirrhosis and HCV non-clearance are significant risk factors.
  • HCV clearance offers a protective effect against hemorrhagic stroke, especially in cirrhotic patients.

Keywords:
hemorrhagic strokehepatitis C virusinterferon therapy

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