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Crystal structure of the nipah virus phosphoprotein tetramerization domain
Jessica F Bruhn1, Katherine C Barnett, Jaclyn Bibby
1Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA.
Abstract:
The Nipah virus phosphoprotein (P) is multimeric and tethers the viral polymerase to the nucleocapsid. We present the crystal structure of the multimerization domain of Nipah virus P: a long, parallel, tetrameric, coiled coil with a small, α-helical cap structure. Across the paramyxoviruses, these domains share little sequence identity yet are similar in length and structural organization, suggesting a common requirement for scaffolding or spatial organization of the functions of P in the virus life cycle.
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