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Mitral Valve Prolapse II: Assessment and Management

IntroductionA range of clinical features characterizes Mitral Valve Prolapse (MVP), but it is important to note that many individuals with MVP are asymptomatic and may remain so throughout their lives. For those who do exhibit symptoms, the following are the key clinical features:Palpitations: This is a common symptom where individuals feel an irregular or rapid heartbeat. Palpitations in MVP are often due to arrhythmias such as premature ventricular contractions or supraventricular...

Aneurysm II: Clinical Manifestations and Diagnostic Studies

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Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...

Cushing Syndrome II: Pathophysiology

Cushing Syndrome II: Pathophysiology

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Cardiomyopathy II: Dilated Cardiomyopathy

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Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...

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Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

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Updated: May 6, 2026

Cox-Maze IV Procedure Concomitant with Valvular Surgery In Situs Inversus Dextrocardia: A Single-Center Experience in China

Cox-Maze IV Procedure Concomitant with Valvular Surgery In Situs Inversus Dextrocardia: A Single-Center Experience in China

Published on: February 11, 2022

Mediastinal choriocarcinoma presenting with syncope.

Constantin A Dasanu¹, Alexei Shimanovsky, Koyal Jain

¹Department of Hematology-Oncology, St. Francis Hospital and Medical Center, Hartford, USA. c_dasanu@yahoo.com

Connecticut Medicine

|October 26, 2013

Summary

Mediastinal choriocarcinomas, rare germ cell tumors in young males, can present with syncope due to superior vena cava (SVC) syndrome. Early chemotherapy led to remission in a unique case, highlighting the importance of considering this diagnosis.

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Last Updated: May 6, 2026

Cox-Maze IV Procedure Concomitant with Valvular Surgery In Situs Inversus Dextrocardia: A Single-Center Experience in China

Cox-Maze IV Procedure Concomitant with Valvular Surgery In Situs Inversus Dextrocardia: A Single-Center Experience in China

Published on: February 11, 2022

Area of Science:

Oncology
Pathology

Background:

Mediastinal choriocarcinomas are rare, aggressive germ cell tumors predominantly affecting young males.
These tumors often present with poor prognoses due to rapid growth and compression of mediastinal structures.

Observation:

A unique case of mediastinal choriocarcinoma presented initially with syncope.
The syncope was attributed to superior vena cava (SVC) syndrome caused by the tumor.

Findings:

The patient received a standard chemotherapy triplet regimen.
Tumor markers normalized after the first chemotherapy cycle.
The patient achieved a 18-month remission with no evidence of disease relapse.

Implications:

Syncope can be an initial clinical manifestation of mediastinal choriocarcinoma in young males.
Early diagnosis and prompt chemotherapy are crucial for favorable outcomes.
Clinicians should consider mediastinal germ cell tumors in the differential diagnosis for young males presenting with syncopal episodes.