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Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
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[Protein kinase C activation induces platelet apoptosis]

Li-Li Zhao1, Meng-Xing Chen, Ming-Yi Zhang

  • 1Laboratory of Hematology and Cell Biology, School of Biological Science and Medical Engineering, Beijing University of Aeronautics and Astronautics, Beijing 100191, China; Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis, Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China.

Zhongguo Shi Yan Xue Ye Xue Za Zhi
|October 26, 2013
PubMed
Summary

Protein kinase C (PKC) activation triggers platelet apoptosis by affecting mitochondrial function and activating caspase-3. This finding reveals a new mechanism regulating platelet count and function.

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