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Chronic cough: a respiratory viewpoint
1North Shore Hospital, Westlake, Auckland, New Zealand.
Current Opinion in Otolaryngology & Head and Neck Surgery
|October 26, 2013
Summary
Chronic cough is a debilitating symptom. Investigations can identify causes, but some patients develop cough hypersensitivity, a heightened cough reflex, particularly in women.
Area of Science:
- Pulmonology
- Clinical Medicine
- Pharmacology
Background:
- Chronic cough significantly impacts quality of life.
- Cough guidelines offer a framework for diagnosis and management.
- Specialist clinics improve diagnostic success rates for chronic cough.
Purpose of the Study:
- Review common causes and investigation of chronic cough.
- Explore unexplained chronic cough.
- Examine the relationship between chronic cough and cough hypersensitivity.
Main Methods:
- Systematic review of literature on chronic cough.
- Analysis of diagnostic approaches in specialist clinics.
- Exploration of cough reflex hypersensitivity.
Main Results:
- A systematic approach aids diagnosis and symptom relief in many chronic cough cases.
- Cough reflex hypersensitivity is a common finding in patients with unexplained or treatment-resistant cough.
- Females are disproportionately represented in tertiary cough clinics, exhibiting heightened cough responses and frequent ACE-inhibitor-induced cough.
Conclusions:
- Understanding of cough has evolved, revealing a distinct group with chronic idiopathic cough and hypersensitivity.
- Further collaboration is needed to elucidate the pathophysiology of enhanced cough reflexes.
- Development of novel antitussive therapies is crucial for effective treatment.
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