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Gene-gene interactions in APOL1-associated nephropathy

Jasmin Divers1, Nicholette D Palmer, Lingyi Lu

  • 1Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
|October 26, 2013
PubMed
Summary

Genetic variants in NPHS2, SDCCAG8, and near BMP4 interact with APOL1 to modify the risk of non-diabetic end-stage kidney disease (ESKD) in African Americans. These findings identify key genetic modifiers for ESKD risk.

Keywords:
APOL1African Americanbone morphogenetic protein 4 (BMP4)kidney diseasepodocin (NPHS2)serologically defined colon cancer antigen 8 (SDCCAG8)

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