Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

16.2K
Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
16.2K
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

9.3K
9.3K
Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

14.7K
Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
14.7K
Fractures: Bone Repair01:27

Fractures: Bone Repair

5.9K
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
5.9K
Bone Remodeling01:40

Bone Remodeling

34.4K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
34.4K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

3.9K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mechanisms of instantaneous inactivation of SARS-CoV-2 by silicon nitride bioceramic.

Materials today. Bio·2021
Same author

Calcium Signaling in T Cells and Chronic Inflammatory Disorders of the Oral Cavity.

Journal of dental research·2021
Same author

Craniomaxillofacial Disorders and Solutions in Humans and Animals.

Journal of dental research·2018
Same author

Mature ferredoxin-NADP reductase with a glutaminyl residue at N-terminus from spinach chloroplasts.

Photosynthesis research·2013
Same author

A role of oral bacteria in bisphosphonate-induced osteonecrosis of the jaw.

Journal of dental research·2011
Same author

Drosophila MAGE controls neural precursor proliferation in postembryonic neurogenesis.

Neuroscience·2008

Related Experiment Video

Updated: May 6, 2026

Bioelectric Analyses of an Osseointegrated Intelligent Implant Design System for Amputees
14:31

Bioelectric Analyses of an Osseointegrated Intelligent Implant Design System for Amputees

Published on: July 15, 2009

15.7K

Genetic networks in osseointegration.

I Nishimura1

  • 1Weintraub Center for Reconstructive Biotechnology, Divisions of Advanced Prosthodontics and Oral Medicine & Biology, UCLA School of Dentistry, Los Angeles, CA 90095-1668.

Journal of Dental Research
|October 26, 2013
PubMed
Summary

Dental implants rely on osseointegration for success. This review explores genetic networks, bone quality, and circadian rhythms to understand the molecular mechanisms behind stable implant integration.

Keywords:
bone remodelingcartilage matrix proteincircadian rhythmdental implantsgene expressionmicroarray analysis

More Related Videos

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration
06:05

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration

Published on: July 14, 2023

1.8K
Author Spotlight: Simple Establishment of a Vascularized Osteogenic Bone Marrow Niche Using Pre-Cast Poly(Ethylene Glycol) (PEG) Hydrogels in an Imaging Microplate
10:32

Author Spotlight: Simple Establishment of a Vascularized Osteogenic Bone Marrow Niche Using Pre-Cast Poly(Ethylene Glycol) (PEG) Hydrogels in an Imaging Microplate

Published on: May 19, 2023

4.0K

Related Experiment Videos

Last Updated: May 6, 2026

Bioelectric Analyses of an Osseointegrated Intelligent Implant Design System for Amputees
14:31

Bioelectric Analyses of an Osseointegrated Intelligent Implant Design System for Amputees

Published on: July 15, 2009

15.7K
Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration
06:05

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration

Published on: July 14, 2023

1.8K
Author Spotlight: Simple Establishment of a Vascularized Osteogenic Bone Marrow Niche Using Pre-Cast Poly(Ethylene Glycol) (PEG) Hydrogels in an Imaging Microplate
10:32

Author Spotlight: Simple Establishment of a Vascularized Osteogenic Bone Marrow Niche Using Pre-Cast Poly(Ethylene Glycol) (PEG) Hydrogels in an Imaging Microplate

Published on: May 19, 2023

4.0K

Area of Science:

  • Biomaterials Science
  • Oral and Maxillofacial Surgery
  • Molecular Biology

Background:

  • Osseointegration is crucial for dental implant success in treating edentulism.
  • The molecular and cellular mechanisms governing stable implant integration remain incompletely understood.
  • Peri-implant bone exhibits remarkable stability, resisting catabolic remodeling, prompting further investigation into implant-induced bone formation.

Purpose of the Study:

  • To review and elucidate the complex molecular and cellular mechanisms regulating osseointegration.
  • To highlight genetic networks and biological pathways involved in the establishment and maintenance of dental implant stability.

Main Methods:

  • Comprehensive review of existing literature, focusing on whole-genome transcriptome studies.
  • Analysis of genetic networks associated with bone quality, chondrogenesis, vitamin D signaling, and circadian rhythms.

Main Results:

  • Identified complex molecular pathways implicated in osseointegration.
  • Highlighted the roles of genetic networks governing bone quality and a transient chondrogenic phase.
  • Emphasized the significance of the vitamin D axis and peripheral circadian rhythms in regulating implant integration.

Conclusions:

  • Osseointegration is a multifaceted process regulated by intricate genetic and molecular pathways.
  • Understanding these mechanisms, including bone quality, chondrogenesis, vitamin D, and circadian rhythms, is key to optimizing dental implant success.
  • Further research into these regulatory mechanisms can enhance the long-term stability and efficacy of dental implants.