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Enterovirus 71 pathogenicity in monkeys and cotton rats
Galina A Koroleva1, Valentina Ya Karmysheva, Alexander N Lukashev
1Chumakov Institute of Poliomyelitis and Viral Encephalitides, p/o Institut Poliomielita, 142782, Moscow, Russia.
Archives of Virology
|October 26, 2013
Summary
Enterovirus 71 (EV71) causes severe central nervous system infections in infants. This study shows that vervet monkeys and young cotton rats can model EV71 neuroinfection, similar to human disease.
Area of Science:
- Virology
- Neuroscience
- Infectious Diseases
Background:
- Enterovirus 71 (EV71) is a significant cause of severe central nervous system (CNS) infections in infants.
- EV71 neuroinfection presents with clinical and pathological signs resembling poliomyelitis.
Purpose of the Study:
- To establish animal models for studying EV71 neuroinfection.
- To compare the pathological outcomes of EV71 infection in different animal species.
Main Methods:
- Vervet monkeys were infected intracerebrally or intramuscularly with EV71 isolates.
- Young cotton rats were experimentally infected with EV71.
- Clinical manifestations and pathological signs were assessed in both species.
Main Results:
- Vervet monkeys developed encephalomyelitis and spinal poliomyelitis similar to human EV71 neuroinfection.
- Severe alterations in the choroid plexus were observed in infected vervet monkeys.
- Young cotton rats exhibited comparable clinical and pathological signs of EV71 neuroinfection.
Conclusions:
- Vervet monkeys serve as a suitable model for EV71-induced central nervous system disease.
- Young cotton rats can also be used to reproduce EV71 neuroinfection, offering a valuable research model.
