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Targeted Cancer Therapies02:57

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
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[Bone targeted therapies: new agents].

Claire Barth1, Christophe Massard, Stéphane Vignot

  • 1Groupe hospitalier Pitié-Salpêtrière - Charles-Foix, pôle ORPHé, 47-83, boulevard de l'Hôpital, 75013 Paris, France.

Bulletin Du Cancer
|October 26, 2013
PubMed
Summary
This summary is machine-generated.

New bone targeting therapies improve understanding of bone remodeling and osteoclastogenesis. This review covers agents targeting factors like TGFβ, PTHrP, Src, Cathepsin K, and chemokines for bone metastasis.

Keywords:
bone targeted therapies

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Area of Science:

  • Bone biology and pharmacology
  • Oncology and endocrinology

Context:

  • Advances in understanding bone remodeling physiology and pathology.
  • Development of bisphosphonates and anti-RANK/RANKL agents.

Purpose:

  • Review the rationale and clinical results of novel bone-targeting therapies.
  • Discuss emerging therapeutic strategies for bone remodeling and metastasis.

Summary:

  • New agents target osteoclastogenesis factors (TGFβ, PTHrP), bone remodeling pathways (Src, Cathepsin K), and tumor cell homing (chemokines).
  • Focus on therapies addressing bone metastasis and related pathological processes.

Impact:

  • Informs clinical practice regarding new bone-targeting agents.
  • Highlights future directions in bone metastasis treatment and bone remodeling modulation.